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IMProv - Integrative Modeling Platform

Developed with funding support from  

Integrative structural biology requires the aggregation of multiple distinct types of data to generate models that satisfy all inputs. Here, we present IMProv, an app in the Mass Spec Studio that seamlessly combines XL–MS data with other structural data, such as cryo-EM densities and crystallographic structures, for integrative structure modeling using IMP (www.integrativemodeling.org).


Configure an IMP run

The app contains a wizard to upload protein sequences, atomic structures, all available modeling data, and the necessary graphical interfaces for setting the protein topology files and the configuration of IMP. The output is a set of scripts generated from basic templates. These are combined with IMP to initiate a modeling run.


Containers for running IMP

The scripts and data are combined with a container that includes IMP and the environment for running it. The template script for the IMP Python Modeling Interface (PMI v2) supports cryo-EM and XL–MS data, partial X-ray structures or homologies, as well as basic physical restraints, such as sequence connectivity and excluded volume. We have developed deployment bundles for Amazon Web Services, personal computers and we maintain an installation on Compute Canada Resources (Cedar). The associated tutorials describe in detail how to take advantage of these resources.

To get started, follow the tutorials in the sidebar.

Get Started

See links below for step-by-step tutorials to use IMProv.

Video Tutorials

About Us

We are the Structural Mass Spectrometry group at the University of Calgary. We use protein mass spectrometry to measure protein structure and dynamics. Our research is driven by fundamental interests in molecular processes related to cell division, DNA damage repair and host-pathogen interactions. We've built several software solutions in the past to complement our research activities. Our goal is to share Mass Spec Studio and enable the mass spec community to build robust analysis workflows which are easy to integrate, maintain and utilize.

Visit our webpage

Contact Us

  • Dept. of Biochemistry & Molecular Biology, Faculty of Medicine, Rm. 379 Heritage Research Building, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
  • dschriem@ucalgary.ca
  • (403) 283-8727
  • (403) 210-3811
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